Research Papers (links are underlined):
Stanbery AG, Newman ZR, Barton GM. Dysregulation of TLR9 in neonates leads to fatal inflammatory disease driven by IFN-γ. Proc Natl Acad Sci USA. (2020) 117:3074-3082
Majer O*, Liu B*, Kreuk LSM, Krogan N, Barton GM. Unc93b1 recruits Syntenin-1 to dampen TLR7 signaling and prevent autoimmunity. Nature (2019) 575:366-370. *equal contribution
Majer O, Liu B, Woo BJ, Kreuk LSM, Van Dis E, Barton GM. Release from Unc93b1 reinforces compartmentalized activation of select Toll-like receptors. Nature (2019) 575:371-374.
Kreuk LS, Koch MA, Slayden LC, Lind NA, Chu S, Savage HP, Kantor AB, Baumgarth N, Barton GM. B cell receptor and Toll-like receptor signaling coordinate to control distinct B-1 responses to both self and microbiota. eLife (2019) 8:e47015
Ansaldo E, Slayden LC, Ching KL, Koch MA, Wolf NK, Plichta DR, Brown EM, Graham DB, Xavier RJ, Moon JJ, Barton GM. Akkermansia muciniphila induces intestinal adaptive immune responses during homeostasis. Science (2019) 364:1179-1184.
Roberts AW, Popov LM, Mitchell G, Ching KL, Licht DJ, Golovkine G, Barton GM, Cox JS. Cas9+ conditionally immortalized macrophages as a tool for bacterial pathogenesis and beyond. eLife (2019) 8:e45957.
Price AE, Shamardani K, Lugo KA, Deguine J, Roberts AW, Lee BL, Barton GM. A Map of Toll-like Receptor Expression in the Intestinal Epithelium Reveals Distinct Spatial, Cell Type-Specific and Temporal Patterns. Immunity (2018) 49:560-575.e6 .
Roberts AW, Lee BL, Deguine J, John S, Schlomchik MJ, Barton GM. Tissue-Resident Macrophages Are Localy Programmed for Silent Clearance of Apoptotic Cells. Immunity (2017) 47:913-927.
Deguine J, Wei J, Barbalat R, Gronert K, Barton GM. Local TNFR1 Signaling Licenses Murine Neutrophils for Increased TLR-Dependent Cytokine and Eicosanoid Production. J Immunol (2017) 198:2865-2875.
Koch MA, Reiner GL, Lugo KA, Kreuk LS, Stanbery AG, Ansaldo E, Seher TD, Ludington WB, Barton GM. Maternal IgG and IgA Antibodies Dampen Mucosal T Helper Cell Responses in Early Life. Cell (2016) 165:827-841.
Newman ZR, Young JM, Ingolia NT, Barton GM. Differences in codon bias and GC content contribute to the balanced expression of TLR7 and TLR9. Proc Natl Acad Sci U S A. (2016) 113:E1362-1371.
Sivick KE, Arpaia N, Reiner GL, Lee BL, Russell BR, Barton GM. Toll-like receptor-deficient mice reveal how innate immune signaling influences salmonella virulence strategies. Cell Host Microbe (2014) 15:203-213.
Deguine J, Lee BL, Newman ZR, Barton GM. No antigen-presentation defect in Unc93b1(3d/3d) 3d mice. Nature Immunology (2013) 14: 1101-1102.
Lee BL, Moon JE, Shu JH, Yuan L, Newman ZR, Schekman R, Barton GM. UNC93B1 mediates differential trafficking of endosomal TLRs, eLife (2013) 2:e00291.
Chiang C, Engel A, Opaluch AM, Ramos I, Maestre AM, Secundino I, De Jesus P, Nguyen QT, Welch B, Bonamy GM, Miraglia LJ, Orth AP, Nizet V, Fernandez-Sesma A, Zhou Y, Barton GM, Chanda SK. Cofactors Required for TLR7- and TLR9- Dependent innate Immune Responses, Cell Host and Microbe (2012) 35:306-318.
Mouchess ML, Arpaia N, Souza G, Barbalat R, Ewald SE, Lau L, Barton GM. Transmembrane Mutations in Toll-like Receptor 9 Bypass the Requirement for Ectodomain Proteolysis and Induce Fatal Inflammation, Immunity (2011) 35:721-732.
Zanoni I, Ostuni R, Marek LR, Barresi S, Barbalat R, Barton GM, Granucci F, Kagan JC. CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4, Cell (2011) 147:868-880.
Ewald SE, Engel A, Lee J, Wang M, Bogyo M, Barton GM. Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase, Journal of Experimental Medicine (2011) 208: 643-651.
Arpaia N, Godec J, Lau L, Sivick KE, McLaughlin LM, Jones MB, Dracheva T, Peterson SN, Monack DM, Barton GM. TLR signaling is required for Salmonella typimurium virulence, Cell (2011) 144:675-688. Video abstract can be found here.
Barbalat R, Lau L, Locksley RM, Barton GM. Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands, Nature Immunology (2009) 10:1200-1207.
Ewald SE, Lee BL, Lau L, Wickliffe KE, Shi GP, Chapman HA, Barton GM. The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor, Nature (2008) 456:658-662.
Reviews, Perspectives, etc:
Majer O, Liu B, Barton GM. Nucleic acid-sensing TLRs: trafficking and regulation. Current Opinion in Immunology (2017) 44:26-33.
Kagan JC, Barton GM. Emerging principles governing signal transduction by pattern-recognition receptors. Cold Spring Harb Prospect Biol (2014) 13:a016253.
Deguine J, Barton GM. MyD88: a central player in innate immune signaling. F1000Prime Reports (2014) 6:97.
Lee BL, Barton GM. Trafficking of endosomal Toll-like receptors. Trends in Cell Biology (2014) 24:360-369
Koch MA, Barton GM. TLR5 stops commensals in their tracks. Cell Host Microbe (2013) 14:488-90.
Arpaia N, Barton GM. The Impact of Toll-like Receptors on Bacterial Virulence Strategies, Current Opinions in Microbiology (2013) 16: 17-22
Arpaia N, Barton GM. Toll-like receptors: key players in antiviral immunity, Current Opinion in Virology (2011) 1:447-454.
Barbalat R, Ewald SE, Mouchess ML, Barton GM. Nucleic Acid Recognition by the Innate Immune System, Annual Review of Immunology (2011) 29:185-214.
Barton GM, Kagan JC. A cell biological view of Toll-like receptor function: regulation through compartmentalization, Nature Reviews Immunology (2009) 9:535-542
Barton GM. A calculated response: control of inflammation by the innate immune system, J. Clin. Invest. (2008) 118:413-420.
Barton GM. Viral recognition by Toll-like receptors, Semin. Immunol. (2007) 19:33-40.